InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EXTL2

Summary

InnateDB Protein

IDBP-100538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXTL2

Protein Name

exostoses (multiple)-like 2

Synonyms

EXTR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359131

InnateDB Gene

IDBG-100534 (EXTL2)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269PubMed:10318803}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001888	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006044	N-acetylglucosamine metabolic process
GO:0008152	metabolic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0019276	UDP-N-acetylgalactosamine metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome