InnateDB Protein
|
IDBP-100541.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SLC30A7
|
Protein Name
|
solute carrier family 30 (zinc transporter), member 7
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000359130
|
InnateDB Gene
|
IDBG-100539 (SLC30A7)
|
Protein Structure
|
|
Function |
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:12446736}; Multi-pass membrane protein {ECO:0000269PubMed:12446736}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008324
|
cation transmembrane transporter activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002524
Cation efflux protein
|
PFAM |
PF01545
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8NEW0
|
PhosphoSite |
PhosphoSite-Q8NEW0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
148867
|
UniGene |
Hs.619680
|
RefSeq |
NP_598003
|
HUGO |
HGNC:19306
|
OMIM |
611149
|
CCDS |
CCDS776
|
HPRD |
15369
|
IMGT |
|
EMBL |
AC104506
AF233345
AF529197
AK313638
AL732465
AY094606
BC064692
BX537375
CH471097
|
GenPept |
AAH64692
AAL83716
AAM21969
AAO17324
BAG36396
CAD97617
CAI13301
EAW72942
EAW72943
|
|
|