InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC30A7

Summary

InnateDB Protein

IDBP-100545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC30A7

Protein Name

solute carrier family 30 (zinc transporter), member 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350278

InnateDB Gene

IDBG-100539 (SLC30A7)

Protein Structure

UniProt Annotation

Function

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:12446736}; Multi-pass membrane protein {ECO:0000269PubMed:12446736}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0044267	cellular protein metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome