Version 5.4
Homo sapiens Protein: PRMT6
Summary
InnateDB Protein IDBP-100615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT6
Protein Name protein arginine methyltransferase 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359095
InnateDB Gene IDBG-100613 (PRMT6)
Protein Structure
UniProt Annotation
Function Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting- induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). {ECO:0000250, ECO:0000269PubMed:11724789, ECO:0000269PubMed:16157300, ECO:0000269PubMed:16159886, ECO:0000269PubMed:16600869, ECO:0000269PubMed:17267505, ECO:0000269PubMed:17898714, ECO:0000269PubMed:18077460, ECO:0000269PubMed:18079182, ECO:0000269PubMed:19405910, ECO:0000269PubMed:19509293, ECO:0000269PubMed:20047962}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11724789}.
Disease Associations
Tissue Specificity Highly expressed in kidney and testis. {ECO:0000269PubMed:11724789}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 172 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 172 [view]
Protein-Protein 172 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016740 transferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0070611 histone methyltransferase activity (H3-R2 specific)
GO:0070612 histone methyltransferase activity (H2A-R3 specific)
Biological Process
GO:0006284 base-excision repair
GO:0006351 transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0016032 viral process
GO:0016571 histone methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034970 histone H3-R2 methylation
GO:0043985 histone H4-R3 methylation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR027555 tRNA (mo5U34)-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF02475
PF05175
PF06325
PF08241
PF05185
PF08003
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LA8
PhosphoSite PhosphoSite-Q96LA8
TrEMBL
UniProt Splice Variant
Entrez Gene 55170
UniGene Hs.644402
RefSeq NP_060607
HUGO HGNC:18241
OMIM 608274
CCDS CCDS41360
HPRD 10505
IMGT
EMBL AK001421 AK295541 AL355539 AY043278 BC002729 BC063446 BC073866 BX475300 CH471156
GenPept AAH02729 AAH63446 AAH73866 AAK85733 BAA91681 BAG58450 CAI19090 EAW51248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca