InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF7

Summary

InnateDB Protein

IDBP-10064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF7

Protein Name

TNF receptor-associated factor 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318944

InnateDB Gene

IDBG-10062 (TRAF7)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. {ECO:0000269PubMed:14743216, ECO:0000269PubMed:15001576}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000269PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. {ECO:0000269PubMed:15001576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0043410	positive regulation of MAPK cascade
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001293 Zinc finger, TRAF-type
IPR001680 WD40 repeat
IPR001841 Zinc finger, RING-type
IPR008974 TRAF-like
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF13639
PF14634

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt