Version 5.4
Homo sapiens Gene: TRAF7
Summary
InnateDB Gene IDBG-10062.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF7
Gene Name TNF receptor-associated factor 7, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131653
Encoded Proteins
IDBP-10064
TNF receptor-associated factor 7
IDBP-753805
IDBP-806606
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
IDBP-806560
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
IDBP-751726
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2155698-2178129
Strand Forward strand
Band p13.3
Transcripts
ENST00000326181 ENSP00000318944
ENST00000567645 ENSP00000456034
ENST00000567653 ENSP00000478515
ENST00000565383 ENSP00000479297
ENST00000570169
ENST00000569686
ENST00000564067 ENSP00000457735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043410 positive regulation of MAPK cascade
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052752
View Gene Order
ENSBTAG00000019073
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 84231
UniGene
RefSeq NM_032271 XM_005255627
HUGO HGNC:20456
OMIM 606692
CCDS CCDS10461
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 84231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca