InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSRC1

Summary

InnateDB Protein

IDBP-100806.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSRC1

Protein Name

proline/serine-rich coiled-coil 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358920

InnateDB Gene

IDBG-100800 (PSRC1)

Protein Structure

UniProt Annotation

Function

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269PubMed:18411309, ECO:0000269PubMed:19738423}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

Disease Associations

Tissue Specificity

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. {ECO:0000269PubMed:12427559}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0007080	mitotic metaphase plate congression
GO:0030308	negative regulation of cell growth
GO:0031116	positive regulation of microtubule polymerization
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060236	regulation of mitotic spindle organization

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody