Version 5.4
Homo sapiens Gene: PSRC1
Summary
InnateDB Gene IDBG-100800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSRC1
Gene Name proline/serine-rich coiled-coil 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134222
Encoded Proteins
IDBP-100802
proline/serine-rich coiled-coil 1
IDBP-100804
proline/serine-rich coiled-coil 1
IDBP-100806
proline/serine-rich coiled-coil 1
IDBP-100810
proline/serine-rich coiled-coil 1
IDBP-294329
proline/serine-rich coiled-coil 1
IDBP-810123
proline/serine-rich coiled-coil 1
IDBP-387534
proline/serine-rich coiled-coil 1
IDBP-387535
proline/serine-rich coiled-coil 1
IDBP-810128
proline/serine-rich coiled-coil 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109279556-109283186
Strand Reverse strand
Band p13.3
Transcripts
ENST00000369909 ENSP00000358925
ENST00000369907 ENSP00000358923
ENST00000369904 ENSP00000358920
ENST00000369903 ENSP00000358919
ENST00000409267 ENSP00000386323
ENST00000409138 ENSP00000474667
ENST00000429031 ENSP00000387791
ENST00000418914 ENSP00000413186
ENST00000492431
ENST00000474126 ENSP00000474682
ENST00000459765
ENST00000471740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0007080 mitotic metaphase plate congression
GO:0009987 cellular process
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060236 regulation of mitotic spindle organization
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068744
View Gene Order
ENSBTAG00000018806
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405925
RefSeq NM_001005290 NM_001032291 NM_032636 XM_005271282 XM_005271283 XM_006710982 XM_006710983 XM_006710984 XM_006710985
HUGO
OMIM
CCDS CCDS30791 CCDS797
HPRD 13127
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca