InnateDB Protein
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IDBP-100810.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSRC1
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Protein Name
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proline/serine-rich coiled-coil 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358919
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InnateDB Gene
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IDBG-100800 (PSRC1)
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Protein Structure
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Function |
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269PubMed:18411309, ECO:0000269PubMed:19738423}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
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Disease Associations |
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Tissue Specificity |
Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. {ECO:0000269PubMed:12427559}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001578
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microtubule bundle formation
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GO:0007080
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mitotic metaphase plate congression
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GO:0030308
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negative regulation of cell growth
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GO:0031116
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positive regulation of microtubule polymerization
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GO:0045737
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positive regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0060236
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regulation of mitotic spindle organization
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PGN9
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PhosphoSite |
PhosphoSite-Q6PGN9
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TrEMBL |
Q5T2Z1
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UniProt Splice Variant |
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Entrez Gene |
84722
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UniGene |
Hs.405925
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RefSeq |
XP_006711045
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HUGO |
HGNC:24472
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OMIM |
613126
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CCDS |
CCDS797
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HPRD |
13127
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IMGT |
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EMBL |
AF223000
AF322891
AF447874
AK126567
AL390252
BC056909
CH471122
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GenPept |
AAH56909
AAN73431
AAN73434
AAQ04649
BAC86599
CAI13172
CAI13173
CAI13174
EAW56373
EAW56375
EAW56377
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