InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTM1

Summary

InnateDB Protein

IDBP-100893.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM1

Protein Name

glutathione S-transferase mu 1

Synonyms

GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000234981

InnateDB Gene

IDBG-100889 (GSTM1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269PubMed:16548513}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver (at protein level). {ECO:0000269PubMed:7822249}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0018916	nitrobenzene metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:0070458	cellular detoxification of nitrogen compound
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003081 Glutathione S-transferase, Mu class
IPR004045 Glutathione S-transferase, N-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM