InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSF1

Summary

InnateDB Protein

IDBP-100930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF1

Protein Name

colony stimulating factor 1 (macrophage)

Synonyms

CSF-1; MCSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000358817

InnateDB Gene

IDBG-100920 (CSF1)

Protein Structure

UniProt Annotation

Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269PubMed:16337366, ECO:0000269PubMed:19934330, ECO:0000269PubMed:20504948, ECO:0000269PubMed:20829061}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:1531650, ECO:0000269PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269PubMed:1531650, ECO:0000269PubMed:3264877}.Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.

Disease Associations

Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005157	macrophage colony-stimulating factor receptor binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0003006	developmental process involved in reproduction
GO:0006954	inflammatory response
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010743	regulation of macrophage derived foam cell differentiation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030225	macrophage differentiation
GO:0030316	osteoclast differentiation
GO:0030335	positive regulation of cell migration
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0042117	monocyte activation
GO:0045087	innate immune response
GO:0045651	positive regulation of macrophage differentiation
GO:0045657	positive regulation of monocyte differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045860	positive regulation of protein kinase activity

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome