Version 5.4
Homo sapiens Gene: CSF1
Summary
InnateDB Gene IDBG-100920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF1
Gene Name colony stimulating factor 1 (macrophage)
Synonyms CSF-1; MCSF
Species Homo sapiens
Ensembl Gene ENSG00000184371
Encoded Proteins
IDBP-100922
colony stimulating factor 1 (macrophage)
IDBP-100924
colony stimulating factor 1 (macrophage)
IDBP-100930
colony stimulating factor 1 (macrophage)
IDBP-100932
colony stimulating factor 1 (macrophage)
IDBP-387591
colony stimulating factor 1 (macrophage)
IDBP-583495
colony stimulating factor 1 (macrophage)
IDBP-594133
colony stimulating factor 1 (macrophage)
IDBP-602685
colony stimulating factor 1 (macrophage)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109910242-109930992
Strand Forward strand
Band p13.3
Transcripts
ENST00000329608 ENSP00000327513
ENST00000357302 ENSP00000349854
ENST00000369802 ENSP00000358817
ENST00000369801 ENSP00000358816
ENST00000420111 ENSP00000407317
ENST00000488198 ENSP00000433837
ENST00000527192 ENSP00000434527
ENST00000525659 ENSP00000431547
ENST00000526001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001503 ossification
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002158 osteoclast proliferation
GO:0003006 developmental process involved in reproduction
GO:0006954 inflammatory response
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030225 macrophage differentiation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0040018 positive regulation of multicellular organism growth
GO:0042117 monocyte activation
GO:0042476 odontogenesis
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0045087 innate immune response
GO:0045651 positive regulation of macrophage differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048873 homeostasis of number of cells within a tissue
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060611 mammary gland fat development
GO:0060763 mammary duct terminal end bud growth
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014599
View Gene Order
ENSBTAG00000000283
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
ptp1bpathway
Signaling events mediated by PTP1B
tcptp_pathway
Signaling events mediated by TCPTP
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.173894
RefSeq NM_000757 NM_172210 NM_172211 NM_172212
HUGO
OMIM
CCDS CCDS30797 CCDS816 CCDS817
HPRD 00388
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca