InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM15

Summary

InnateDB Protein

IDBP-100968.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM15

Protein Name

RNA binding motif protein 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358799

InnateDB Gene

IDBG-100966 (RBM15)

Protein Structure

UniProt Annotation

Function

May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation. {ECO:0000269PubMed:17001072, ECO:0000269PubMed:19786495}.

Subcellular Localization

Nucleus. Nucleus membrane; Peripheral membrane protein. Note=Colocalizes at the nuclear pore with DBP5 and NXF1.

Disease Associations

Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	23 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001569	patterning of blood vessels
GO:0007221	positive regulation of transcription of Notch receptor target
GO:0016032	viral process
GO:0045638	negative regulation of myeloid cell differentiation
GO:0048536	spleen development
GO:0060412	ventricular septum morphogenesis
GO:0060674	placenta blood vessel development

Cellular Component

GO:0005634	nucleus
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR010912 Spen paralogue/orthologue C-terminal, metazoa
IPR012921 Spen paralogue and orthologue SPOC, C-terminal
IPR016194 SPOC like C-terminal domain

PFAM

PF00076
PF07744

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96T37