Version 5.4
Homo sapiens Protein: LRIF1
Summary
InnateDB Protein IDBP-101009.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRIF1
Protein Name ligand dependent nuclear receptor interacting factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358778
InnateDB Gene IDBG-101007 (LRIF1)
Protein Structure
UniProt Annotation
Function Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recruitment of histone deacetylases. {ECO:0000269PubMed:17455211}.
Subcellular Localization Nucleus matrix {ECO:0000269PubMed:17455211}.
Disease Associations
Tissue Specificity Widely expressed, with the highest expression levels in heart, liver and placenta. {ECO:0000269PubMed:17455211}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 159 experimentally validated interaction(s) in this database.
Experimentally validated
Total 159 [view]
Protein-Protein 159 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042974 retinoic acid receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T3J3
PhosphoSite PhosphoSite-Q5T3J3
TrEMBL
UniProt Splice Variant
Entrez Gene 55791
UniGene Hs.669780
RefSeq NP_060842
HUGO HGNC:30299
OMIM 615354
CCDS CCDS30800
HPRD 17975
IMGT
EMBL AK001826 AK002131 AL360270 AL834466 AY190122 BC008115
GenPept AAH08115 AAO43631 BAA91928 BAA92097 CAD39125 CAI17128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca