InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1A

Summary

InnateDB Protein

IDBP-101089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1A

Protein Name

RAP1A, member of RAS oncogene family

Synonyms

C21KG; G-22K; KREV-1; KREV1; RAP1; SMGP21;

Species

Homo sapiens

Ensembl Protein

ENSP00000348786

InnateDB Gene

IDBG-101087 (RAP1A)

Protein Structure

UniProt Annotation

Function

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269PubMed:17916086, ECO:0000269PubMed:21840392}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11359771}; Lipid-anchor {ECO:0000269PubMed:11359771}. Cytoplasm {ECO:0000269PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008565	protein transporter activity
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0032403	protein complex binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0010976	positive regulation of neuron projection development
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0044281	small molecule metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt