InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT2B

Summary

InnateDB Protein

IDBP-101114.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT2B

Protein Name

wingless-type MMTV integration site family, member 2B

Synonyms

WNT13;

Species

Homo sapiens

Ensembl Protein

ENSP00000358700

InnateDB Gene

IDBG-101110 (WNT2B)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0002088	lens development in camera-type eye
GO:0007275	multicellular organismal development
GO:0008584	male gonad development
GO:0016055	Wnt signaling pathway
GO:0021871	forebrain regionalization
GO:0030182	neuron differentiation
GO:0045165	cell fate commitment
GO:0061072	iris morphogenesis
GO:0061303	cornea development in camera-type eye
GO:0071425	hematopoietic stem cell proliferation
GO:0090263	positive regulation of canonical Wnt signaling pathway