Version 5.4
Homo sapiens Gene: WNT2B
Summary
InnateDB Gene IDBG-101110.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT2B
Gene Name wingless-type MMTV integration site family, member 2B
Synonyms WNT13
Species Homo sapiens
Ensembl Gene ENSG00000134245
Encoded Proteins
IDBP-101112
wingless-type MMTV integration site family, member 2B
IDBP-101114
wingless-type MMTV integration site family, member 2B
IDBP-101116
wingless-type MMTV integration site family, member 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23785285
Secretion of WNT2B upon virus infection negatively regulates antiviral innate immunity.
Entrez Gene
Summary This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants. [provided by RefSeq, Aug 2008]
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:112466541-112530165
Strand Forward strand
Band p13.2
Transcripts
ENST00000256640 ENSP00000256640
ENST00000369686 ENSP00000358700
ENST00000369684 ENSP00000358698
ENST00000478360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005515 protein binding
Biological Process
GO:0002062 chondrocyte differentiation
GO:0002088 lens development in camera-type eye
GO:0007275 multicellular organismal development
GO:0008584 male gonad development
GO:0009267 cellular response to starvation
GO:0016055 Wnt signaling pathway
GO:0021871 forebrain regionalization
GO:0030182 neuron differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045165 cell fate commitment
GO:0060070 canonical Wnt signaling pathway
GO:0060492 lung induction
GO:0060638 mesenchymal-epithelial cell signaling
GO:0061072 iris morphogenesis
GO:0061303 cornea development in camera-type eye
GO:0071425 hematopoietic stem cell proliferation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027840
View Gene Order
ENSBTAG00000014291
Not yet available
Pathways
NETPATH
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_21340
GPCR ligand binding pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.258575 Hs.664796
RefSeq NM_001291880 NM_004185 NM_024494
HUGO
OMIM
CCDS CCDS846 CCDS847
HPRD 03574
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca