InnateDB Protein
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IDBP-101116.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WNT2B
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Protein Name
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wingless-type MMTV integration site family, member 2B
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Synonyms
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WNT13;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358698
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InnateDB Gene
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IDBG-101110 (WNT2B)
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Protein Structure
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Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005817
Wnt
IPR009140
Wnt-2 protein
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PFAM |
PF00110
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PRINTS |
PR01349
PR01842
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PIRSF |
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SMART |
SM00097
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TIGRFAMs |
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Modification |
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SwissProt |
Q93097
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5TEH9
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UniProt Splice Variant |
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Entrez Gene |
7482
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UniGene |
Hs.664796
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RefSeq |
NP_078613
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HUGO |
HGNC:12781
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OMIM |
601968
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CCDS |
CCDS847
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HPRD |
03574
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IMGT |
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EMBL |
AB045116
AB045117
AF028701
AK312696
AL109932
AL354760
BC141825
CH471122
Z71621
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GenPept |
AAC39552
AAI41826
BAB11984
BAB11985
BAG35575
CAA96283
CAI22309
CAI22706
EAW56519
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