InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPZA1

Summary

InnateDB Protein

IDBP-101150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPZA1

Protein Name

capping protein (actin filament) muscle Z-line, alpha 1

Synonyms

CAPPA1; CAPZ; CAZ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263168

InnateDB Gene

IDBG-101148 (CAPZA1)

Protein Structure

UniProt Annotation

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	56 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0006461	protein complex assembly
GO:0006928	cellular component movement
GO:0007596	blood coagulation
GO:0030036	actin cytoskeleton organization
GO:0045087	innate immune response
GO:0051016	barbed-end actin filament capping
GO:0051693	actin filament capping

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0008290	F-actin capping protein complex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0071203	WASH complex