InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN22

Summary

InnateDB Protein

IDBP-101226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN22

Protein Name

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352833

InnateDB Gene

IDBG-101222 (PTPN22)

Protein Structure

UniProt Annotation

Function

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. {ECO:0000269PubMed:16461343, ECO:0000269PubMed:18056643, ECO:0000269PubMed:19167335, ECO:0000269PubMed:21719704}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:15273934}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding
GO:0019900	kinase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0030217	T cell differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035644	phosphoanandamide dephosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050868	negative regulation of T cell activation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR016276 Non-receptor tyrosine-protein phosphatase, 8/22
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000930

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References