InnateDB Protein
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IDBP-101267.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HIPK1
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Protein Name
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homeodomain interacting protein kinase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000340956
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InnateDB Gene
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IDBG-101257 (HIPK1)
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Protein Structure
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Function |
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. {ECO:0000269PubMed:12702766, ECO:0000269PubMed:12968034, ECO:0000269PubMed:15701637, ECO:0000269PubMed:16390825, ECO:0000269PubMed:19646965}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. {ECO:0000269PubMed:12529400, ECO:0000269PubMed:12702766}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000719
Protein kinase domain
IPR011009
Protein kinase-like domain
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PFAM |
PF00069
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86Z02
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PhosphoSite |
PhosphoSite-Q86Z02
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TrEMBL |
A0A024R0H9
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UniProt Splice Variant |
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Entrez Gene |
204851
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UniGene |
Hs.691436
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RefSeq |
NP_938010
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HUGO |
HGNC:19006
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OMIM |
608003
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CCDS |
CCDS41370
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HPRD |
06418
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IMGT |
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EMBL |
AB014530
AB089957
AL137856
AL731797
AL833829
BC028408
BC033012
BC036057
CH471122
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GenPept |
AAH28408
AAH33012
AAH36057
BAA31605
BAC57075
CAD38689
CAI22792
CAI22793
CAI22795
EAW56590
EAW56593
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