Version 5.4
Homo sapiens Gene: HIPK1
Summary
InnateDB Gene IDBG-101257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIPK1
Gene Name homeodomain interacting protein kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163349
Encoded Proteins
IDBP-101259
homeodomain interacting protein kinase 1
IDBP-101261
homeodomain interacting protein kinase 1
IDBP-101263
homeodomain interacting protein kinase 1
IDBP-101265
homeodomain interacting protein kinase 1
IDBP-101267
homeodomain interacting protein kinase 1
IDBP-101271
homeodomain interacting protein kinase 1
IDBP-101273
homeodomain interacting protein kinase 1
IDBP-387823
homeodomain interacting protein kinase 1
IDBP-478802
homeodomain interacting protein kinase 1
IDBP-476622
homeodomain interacting protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:113929192-113977804
Strand Forward strand
Band p13.2
Transcripts
ENST00000369561 ENSP00000358574
ENST00000369559 ENSP00000358572
ENST00000369558 ENSP00000358571
ENST00000369555 ENSP00000358568
ENST00000340480 ENSP00000340956
ENST00000369553 ENSP00000358566
ENST00000361587 ENSP00000355191
ENST00000426820 ENSP00000407442
ENST00000514621 ENSP00000422322
ENST00000503968 ENSP00000426695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001654 eye development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842 retina layer formation
GO:0016926 protein desumoylation
GO:0030182 neuron differentiation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045766 positive regulation of angiogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060216 definitive hemopoiesis
GO:0060235 lens induction in camera-type eye
GO:0061072 iris morphogenesis
GO:0072577 endothelial cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008730
View Gene Order
ENSBTAG00000011322
Not yet available
Pathways
NETPATH
REACTOME
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532363 Hs.630911 Hs.691436
RefSeq NM_152696 NM_181358 NM_198268 NM_198269 XM_005270609 XM_005270610 XM_005270612 XM_005270613
HUGO
OMIM
CCDS CCDS41370 CCDS867 CCDS868 CCDS869
HPRD 06418
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca