Version 5.4
Homo sapiens Protein: TSPAN2
Summary
InnateDB Protein IDBP-101342.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN2
Protein Name tetraspanin 2
Synonyms NET3; TSN2; TSPAN-2;
Species Homo sapiens
Ensembl Protein ENSP00000358529
InnateDB Gene IDBG-101340 (TSPAN2)
Protein Structure
UniProt Annotation
Function May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006954 inflammatory response
GO:0007420 brain development
GO:0014002 astrocyte development
GO:0014005 microglia development
GO:0042552 myelination
GO:0048709 oligodendrocyte differentiation
GO:0061564 axon development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043209 myelin sheath
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60636
PhosphoSite PhosphoSite-O60636
TrEMBL
UniProt Splice Variant
Entrez Gene 10100
UniGene Hs.310458
RefSeq NP_005716
HUGO HGNC:20659
OMIM 613133
CCDS CCDS881
HPRD 18233
IMGT
EMBL AF054839 AL109660 BC021675 GU971730
GenPept AAC69715 AAH21675 ADF80915 CAI22271

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca