InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TTF2

Summary

InnateDB Protein

IDBP-101432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTF2

Protein Name

transcription termination factor, RNA polymerase II

Synonyms

HuF2; ZGRF6;

Species

Homo sapiens

Ensembl Protein

ENSP00000358478

InnateDB Gene

IDBG-101430 (TTF2)

Protein Structure

UniProt Annotation

Function

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269PubMed:10455150, ECO:0000269PubMed:12927788, ECO:0000269PubMed:15125840, ECO:0000269PubMed:9748214}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15125840}. Nucleus {ECO:0000269PubMed:15125840}. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0008152	metabolic process
GO:0008380	RNA splicing

Cellular Component

GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0008023	transcription elongation factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR010666 Zinc finger, GRF-type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851
PF06839

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UNY4