InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VTCN1

Summary

InnateDB Protein

IDBP-101442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VTCN1

Protein Name

V-set domain containing T cell activation inhibitor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358470

InnateDB Gene

IDBG-101440 (VTCN1)

Protein Structure

UniProt Annotation

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250UniProtKB:Q7TSP5, ECO:0000269PubMed:15878339, ECO:0000269PubMed:16606666, ECO:0000269PubMed:17509674, ECO:0000269PubMed:17875732}.

Subcellular Localization

Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269PubMed:12818165, ECO:0000269PubMed:15878339, ECO:0000269PubMed:16782226}.

Disease Associations

Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269PubMed:12818165, ECO:0000269PubMed:14568939, ECO:0000269PubMed:15878339, ECO:0000269PubMed:16606666, ECO:0000269PubMed:16782226, ECO:0000269PubMed:16798883, ECO:0000269PubMed:17509674}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0002376	immune system process
GO:0042102	positive regulation of T cell proliferation
GO:0050868	negative regulation of T cell activation
GO:0072602	interleukin-4 secretion
GO:0072643	interferon-gamma secretion
GO:1900042	positive regulation of interleukin-2 secretion