InnateDB Protein
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IDBP-101480.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TBX15
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Protein Name
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T-box 15
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Synonyms
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TBX14;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000207157
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InnateDB Gene
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IDBG-101478 (TBX15)
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Protein Structure
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Function |
Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.
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Disease Associations |
Cousin syndrome (COUSS) [MIM:260660]: Defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. {ECO:0000269PubMed:19068278}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000976
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transcription regulatory region sequence-specific DNA binding
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GO:0001106
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RNA polymerase II transcription corepressor activity
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0042803
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protein homodimerization activity
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GO:0046982
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protein heterodimerization activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0048701
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embryonic cranial skeleton morphogenesis
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GO:0048704
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embryonic skeletal system morphogenesis
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Cellular Component |
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PDB ID |
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InterPro |
IPR001699
Transcription factor, T-box
IPR008967
p53-like transcription factor, DNA-binding
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PFAM |
PF00907
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PRINTS |
PR00937
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PIRSF |
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SMART |
SM00425
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TIGRFAMs |
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Modification |
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SwissProt |
Q96SF7
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PhosphoSite |
PhosphoSite-Q96SF7
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TrEMBL |
Q8N8P2
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UniProt Splice Variant |
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Entrez Gene |
6913
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UniGene |
Hs.626431
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RefSeq |
NP_689593
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HUGO |
HGNC:11594
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OMIM |
604127
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CCDS |
CCDS30816
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HPRD |
16035
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IMGT |
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EMBL |
AK096396
AK127536
AL139420
AL357045
BC122553
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GenPept |
AAI22554
BAC04776
BAG54518
CAI22503
CAI43066
CAI43068
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