InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUOX1

Summary

InnateDB Protein

IDBP-10162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUOX1

Protein Name

dual oxidase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373689

InnateDB Gene

IDBG-10154 (DUOX1)

Protein Structure

UniProt Annotation

Function

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269PubMed:11514595, ECO:0000269PubMed:12824283}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:10806195, ECO:0000269PubMed:15210697}; Multi- pass membrane protein {ECO:0000269PubMed:10806195, ECO:0000269PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.

Disease Associations

Tissue Specificity

Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269PubMed:10806195, ECO:0000269PubMed:11514595, ECO:0000269PubMed:12824283, ECO:0000269PubMed:15210697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050661	NADP binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0006979	response to oxidative stress
GO:0019221	cytokine-mediated signaling pathway
GO:0042335	cuticle development
GO:0042446	hormone biosynthetic process
GO:0042554	superoxide anion generation
GO:0042744	hydrogen peroxide catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR010255 Haem peroxidase
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR019791 Haem peroxidase, animal

PFAM