InnateDB Protein
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IDBP-10167.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NKX3-2
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Protein Name
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NK3 homeobox 2
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Synonyms
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BAPX1; NKX3.2; NKX3B; SMMD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371875
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InnateDB Gene
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IDBG-10163 (NKX3-2)
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Protein Structure
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Function |
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD) [MIM:613330]: A skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphyseal ossification centers and wide growth plates in the long tubular bones, and numerous pseudoepiphyses of the short tubular bones in hands and feet. {ECO:0000269PubMed:20004766}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton. {ECO:0000269PubMed:20004766}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
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PFAM |
PF00046
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PRINTS |
PR00024
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
P78367
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PhosphoSite |
PhosphoSite-P78367
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
579
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UniGene |
Hs.590927
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RefSeq |
NP_001180
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HUGO |
HGNC:951
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OMIM |
602183
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CCDS |
CCDS3410
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HPRD |
09075
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IMGT |
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EMBL |
AF005260
AF009801
AF009802
BC111966
U89845
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GenPept |
AAB49696
AAB82783
AAB82784
AAC39536
AAI11967
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