Version 5.4
Homo sapiens Gene: NKX3-2
Summary
InnateDB Gene IDBG-10163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX3-2
Gene Name NK3 homeobox 2
Synonyms BAPX1; NKX3.2; NKX3B; SMMD
Species Homo sapiens
Ensembl Gene ENSG00000109705
Encoded Proteins
IDBP-10167
NK3 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:13540830-13545050
Strand Reverse strand
Band p15.33
Transcripts
ENST00000382438 ENSP00000371875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007368 determination of left/right symmetry
GO:0031016 pancreas development
GO:0032331 negative regulation of chondrocyte differentiation
GO:0042474 middle ear morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0048513 organ development
GO:0048536 spleen development
GO:0048645 organ formation
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0055123 digestive system development
GO:0060576 intestinal epithelial cell development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049691
View Gene Order
ENSBTAG00000010896
Not yet available
Cross-References
SwissProt P78367
TrEMBL
UniProt Splice Variant
Entrez Gene 579
UniGene Hs.105941 Hs.590927
RefSeq NM_001189
HUGO HGNC:951
OMIM 602183
CCDS CCDS3410
HPRD
IMGT
EMBL AF005260 AF009801 AF009802 BC111966 U89845
GenPept AAB49696 AAB82783 AAB82784 AAC39536 AAI11967
RNA Seq Atlas 579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca