InnateDB Protein
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IDBP-101763.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR3C
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide C (62kD)
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Synonyms
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RPC3; RPC62;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000334564
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InnateDB Gene
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IDBG-101761 (POLR3C)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269PubMed:19609254, ECO:0000269PubMed:19631370}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006359
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regulation of transcription from RNA polymerase III promoter
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0006385
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transcription elongation from RNA polymerase III promoter
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GO:0006386
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termination of RNA polymerase III transcription
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GO:0010467
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gene expression
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GO:0032481
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positive regulation of type I interferon production
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GO:0032728
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positive regulation of interferon-beta production
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GO:0045087
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innate immune response
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GO:0045089
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positive regulation of innate immune response
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GO:0051607
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defense response to virus
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Cellular Component |
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PDB ID |
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InterPro |
IPR008806
RNA polymerase III Rpc82, C -terminal
IPR013197
RNA polymerase III subunit RPC82-related, helix-turn-helix
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PFAM |
PF05645
PF08221
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUI4
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PhosphoSite |
PhosphoSite-Q9BUI4
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TrEMBL |
A0A024R4C1
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UniProt Splice Variant |
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Entrez Gene |
10623
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UniGene |
Hs.591457
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RefSeq |
NP_006459
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HUGO |
HGNC:30076
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OMIM |
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CCDS |
CCDS72864
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HPRD |
17880
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IMGT |
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EMBL |
AJ238221
AJ238222
AJ238223
AJ238224
AJ238225
AJ238226
AJ238227
AJ238228
AJ238229
AJ238230
AJ238231
AJ238232
AJ238233
AJ238234
AY091463
BC002586
CH471244
U93867
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GenPept |
AAB63675
AAH02586
AAM12033
CAB41919
EAW71435
EAW71436
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