InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL9

Summary

InnateDB Protein

IDBP-101831.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL9

Protein Name

B-cell CLL/lymphoma 9

Synonyms

LGS;

Species

Homo sapiens

Ensembl Protein

ENSP00000234739

InnateDB Gene

IDBG-101829 (BCL9)

Protein Structure

UniProt Annotation

Function

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.

Tissue Specificity

Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding

Biological Process

GO:0014908	myotube differentiation involved in skeletal muscle regeneration
GO:0035019	somatic stem cell maintenance
GO:0035914	skeletal muscle cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway