Version 5.4
Homo sapiens Gene: BCL9
Summary
InnateDB Gene IDBG-101829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL9
Gene Name B-cell CLL/lymphoma 9
Synonyms LGS
Species Homo sapiens
Ensembl Gene ENSG00000116128
Encoded Proteins
IDBP-101831
B-cell CLL/lymphoma 9
IDBP-807031
B-cell CLL/lymphoma 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:147541412-147626216
Strand Forward strand
Band q21.2
Transcripts
ENST00000234739 ENSP00000234739
ENST00000497938
ENST00000473292
ENST00000622552 ENSP00000479694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
Biological Process
GO:0014908 myotube differentiation involved in skeletal muscle regeneration
GO:0035019 somatic stem cell maintenance
GO:0035914 skeletal muscle cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038256
View Gene Order
ENSBTAG00000002422
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004326 XM_005272971 XM_006711483
HUGO
OMIM
CCDS CCDS30833
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca