InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CERS2

Summary

InnateDB Protein

IDBP-102227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CERS2

Protein Name

ceramide synthase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000271688

InnateDB Gene

IDBG-102223 (CERS2)

Protein Structure

UniProt Annotation

Function

Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Subcellular Localization

Nucleus membrane {ECO:0000255PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, brain, heart, placenta and lung. {ECO:0000269PubMed:11543633}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006665	sphingolipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane