Version 5.4
Homo sapiens Gene: CERS2
Summary
InnateDB Gene IDBG-102223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CERS2
Gene Name ceramide synthase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143418
Encoded Proteins
IDBP-102225
ceramide synthase 2
IDBP-102227
ceramide synthase 2
IDBP-102229
ceramide synthase 2
IDBP-102231
ceramide synthase 2
IDBP-388417
ceramide synthase 2
IDBP-388420
ceramide synthase 2
IDBP-592258
ceramide synthase 2
IDBP-597579
ceramide synthase 2
IDBP-599758
ceramide synthase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150960583-150975004
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368954 ENSP00000357950
ENST00000271688 ENSP00000271688
ENST00000361419 ENSP00000355020
ENST00000368949 ENSP00000357945
ENST00000345896
ENST00000421609 ENSP00000393239
ENST00000457392 ENSP00000394012
ENST00000482825
ENST00000460664
ENST00000561294 ENSP00000454160
ENST00000560793 ENSP00000453297
ENST00000559660
ENST00000558062 ENSP00000452810
ENST00000559020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0050291 sphingosine N-acyltransferase activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006665 sphingolipid metabolic process
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046513 ceramide biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015714
View Gene Order
ENSBTAG00000000099
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5SZE2
UniProt Splice Variant
Entrez Gene 29956
UniGene Hs.713103 Hs.743745
RefSeq NM_022075 NM_181746 XM_005245107
HUGO HGNC:14076
OMIM 606920
CCDS CCDS973
HPRD 06080
IMGT
EMBL AL590133
GenPept
RNA Seq Atlas 29956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca