InnateDB Protein
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IDBP-10229.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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A4GALT
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Protein Name
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alpha 1,4-galactosyltransferase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370678
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InnateDB Gene
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IDBG-10225 (A4GALT)
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Protein Structure
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Function |
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008378
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galactosyltransferase activity
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GO:0050512
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lactosylceramide 4-alpha-galactosyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007577
Glycosyltransferase, DXD sugar-binding motif
IPR007652
Alpha 1,4-glycosyltransferase domain
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PFAM |
PF04488
PF04572
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NPC4
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PhosphoSite |
PhosphoSite-Q9NPC4
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TrEMBL |
S6CQT5
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UniProt Splice Variant |
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Entrez Gene |
53947
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UniGene |
Hs.105956
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RefSeq |
XP_005261703
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HUGO |
HGNC:18149
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OMIM |
607922
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CCDS |
CCDS14041
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HPRD |
06390
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IMGT |
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EMBL |
AB037883
AB041418
AF513326
AF513327
AJ245581
AK312927
AY941797
BC017068
CH471138
HE818931
HE818932
KC202808
Z82176
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GenPept |
AAH17068
AAP47167
AAP47168
AAX20109
AGF29465
BAA94503
BAA95915
BAG35771
CAB93532
CAI18757
CCH64301
CCH64302
EAW73274
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