Version 5.4
Homo sapiens Gene: A4GALT
Summary
InnateDB Gene IDBG-10225.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A4GALT
Gene Name alpha 1,4-galactosyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128274
Encoded Proteins
IDBP-10227
alpha 1,4-galactosyltransferase
IDBP-10229
alpha 1,4-galactosyltransferase
IDBP-293020
alpha 1,4-galactosyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42692121-42721298
Strand Reverse strand
Band q13.2
Transcripts
ENST00000249005 ENSP00000249005
ENST00000381278 ENSP00000370678
ENST00000401850 ENSP00000384794
ENST00000483026
ENST00000465765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0015643 toxic substance binding
GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity
Biological Process
GO:0001576 globoside biosynthetic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0007009 plasma membrane organization
Cellular Component
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047878
View Gene Order
ENSBTAG00000026497
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00603
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9NPC4
TrEMBL M1KVK7 Q7Z2I1 S6CPX2 S6CQT5
UniProt Splice Variant
Entrez Gene 53947
UniGene Hs.105956
RefSeq NM_017436 XM_005261643 XM_005261644 XM_005261646 XM_005261647 XM_005261648 XM_006724265 XM_006724266
HUGO HGNC:18149
OMIM 607922
CCDS CCDS14041
HPRD
IMGT
EMBL AB037883 AB041418 AF513326 AF513327 AJ245581 AK312927 AY941797 BC017068 CH471138 HE818931 HE818932 KC202808 Z82176
GenPept AAH17068 AAP47167 AAP47168 AAX20109 AGF29465 BAA94503 BAA95915 BAG35771 CAB93532 CAI18757 CCH64301 CCH64302 EAW73274
RNA Seq Atlas 53947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca