Version 5.4
Homo sapiens Protein: SELENBP1
Summary
InnateDB Protein IDBP-102365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELENBP1
Protein Name selenium binding protein 1
Synonyms HEL-S-134P; hSBP; LPSB; SBP56; SP56;
Species Homo sapiens
Ensembl Protein ENSP00000357861
InnateDB Gene IDBG-102363 (SELENBP1)
Protein Structure
UniProt Annotation
Function Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. {ECO:0000269PubMed:14991897, ECO:0000269PubMed:16223876, ECO:0000269PubMed:16380993, ECO:0000269PubMed:16645984, ECO:0000269PubMed:9679983}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008430 selenium binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008826 Selenium-binding protein
PFAM PF05694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13228
PhosphoSite PhosphoSite-Q13228
TrEMBL V9HWG1
UniProt Splice Variant
Entrez Gene 8991
UniGene Hs.632460
RefSeq NP_003935
HUGO HGNC:10719
OMIM 604188
CCDS CCDS995
HPRD 05007
IMGT
EMBL AK296661 AK303815 AK315643 AL391069 BC009084 BC032997 CH471121 CR456852 EU794660 U29091
GenPept AAB02395 AAH09084 AAH32997 ACJ13714 BAG38010 BAG59258 BAG64765 CAG33133 CAH70328 EAW53443 EAW53445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca