InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELF3

Summary

InnateDB Protein

IDBP-102405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELF3

Protein Name

CUGBP, Elav-like family member 3

Synonyms

BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000290583

InnateDB Gene

IDBG-102401 (CELF3)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:15009664}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:11158314}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0007283	spermatogenesis
GO:0008380	RNA splicing
GO:0030317	sperm motility
GO:0048026	positive regulation of mRNA splicing, via spliceosome