Homo sapiens Protein: TDRKH | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-102425.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TDRKH | ||||||||||||||||||
Protein Name | tudor and KH domain containing | ||||||||||||||||||
Synonyms | TDRD2; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000357819 | ||||||||||||||||||
InnateDB Gene | IDBG-102423 (TDRKH) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline (By similarity). {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002999
Tudor domain IPR004087 K Homology domain IPR004088 K Homology domain, type 1 |
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PFAM |
PF00567
PF00013 PF13014 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00333
SM00322 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9Y2W6 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y2W6 | ||||||||||||||||||
TrEMBL | Q9NYV3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 11022 | ||||||||||||||||||
UniGene | Hs.678661 | ||||||||||||||||||
RefSeq | NP_006853 | ||||||||||||||||||
HUGO | HGNC:11713 | ||||||||||||||||||
OMIM | 609501 | ||||||||||||||||||
CCDS | CCDS41394 | ||||||||||||||||||
HPRD | 15485 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF119121 AF227192 AF227634 AK295948 AL589765 BC022467 CH471121 | ||||||||||||||||||
GenPept | AAD30971 AAF36701 AAF68379 BAG58730 CAI17175 CAI17177 EAW53409 EAW53410 EAW53411 | ||||||||||||||||||