Version 5.4
Homo sapiens Protein: FLG2
Summary
InnateDB Protein IDBP-102476.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLG2
Protein Name filaggrin family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373370
InnateDB Gene IDBG-102488 (FLG2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
Biological Process
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR003303 Filaggrin
IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
PFAM PF00036
PF13202
PF13405
PF03516
PF01023
PRINTS PR00487
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5D862
PhosphoSite PhosphoSite-Q5D862
TrEMBL
UniProt Splice Variant
Entrez Gene 388698
UniGene Hs.156124
RefSeq NP_001014364
HUGO HGNC:33276
OMIM
CCDS CCDS30861
HPRD 11815
IMGT
EMBL AL356504 AY827490 DQ118293
GenPept AAX12417 AAZ99029 CAC13173

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca