Version 5.4
| Homo sapiens Protein: CRNN | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-102493.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CRNN | ||||||||||||||||||
| Protein Name | cornulin | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000271835 | ||||||||||||||||||
| InnateDB Gene | IDBG-102491 (CRNN) | ||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||
| UniProt Annotation | |||||||||||||||||||
| Function | Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. {ECO:0000269PubMed:15896671, ECO:0000269PubMed:16640557}. | ||||||||||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:15854041, ECO:0000269PubMed:16640557}. Note=Does not colocalize with TGM1. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269PubMed:11056050, ECO:0000269PubMed:11606197, ECO:0000269PubMed:15854041, ECO:0000269PubMed:15896671, ECO:0000269PubMed:16466100, ECO:0000269PubMed:16640557, ECO:0000269PubMed:17289885}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR002048
EF-hand domain IPR013787 S100/CaBP-9k-type, calcium binding, subdomain |
||||||||||||||||||
| PFAM |
PF00036
PF13202 PF13405 PF01023 |
||||||||||||||||||
| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART |
SM00054
|
||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UBG3 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q9UBG3 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 49860 | ||||||||||||||||||
| UniGene | Hs.242057 | ||||||||||||||||||
| RefSeq | NP_057274 | ||||||||||||||||||
| HUGO | HGNC:1230 | ||||||||||||||||||
| OMIM | 611312 | ||||||||||||||||||
| CCDS | CCDS1010 | ||||||||||||||||||
| HPRD | 12720 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF077831 AF185276 AK316568 AL135842 BC030807 CH471121 | ||||||||||||||||||
| GenPept | AAD55747 AAF00514 AAH30807 BAG38157 CAI23349 EAW53381 | ||||||||||||||||||