InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGLYRP4

Summary

InnateDB Protein

IDBP-102641.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP4

Protein Name

peptidoglycan recognition protein 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357728

InnateDB Gene

IDBG-102639 (PGLYRP4)

Protein Structure

UniProt Annotation

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269PubMed:16354652}.

Subcellular Localization

Secreted {ECO:0000269PubMed:16354652}.

Disease Associations

Tissue Specificity

Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus. {ECO:0000269PubMed:11461926, ECO:0000269PubMed:16354652}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium