Version 5.4
Homo sapiens Protein: ECI1
Summary
InnateDB Protein IDBP-10274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECI1
Protein Name enoyl-CoA delta isomerase 1
Synonyms DCI;
Species Homo sapiens
Ensembl Protein ENSP00000301729
InnateDB Gene IDBG-10272 (ECI1)
Protein Structure
UniProt Annotation
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004165 dodecenoyl-CoA delta-isomerase activity
GO:0016860 intramolecular oxidoreductase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain
PFAM PF00378
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42126
PhosphoSite PhosphoSite-P42126
TrEMBL Q96DC0
UniProt Splice Variant
Entrez Gene 1632
UniGene
RefSeq NP_001910
HUGO HGNC:2703
OMIM 600305
CCDS CCDS10464
HPRD 02628
IMGT
EMBL AC009065 AK291127 BC000762 BC002746 BC009631 BC019316 BC020228 CH471112 L24774 Z25820 Z25821 Z25822 Z25823 Z25824
GenPept AAA35485 AAH00762 AAH02746 AAH09631 AAH19316 AAH20228 BAF83816 CAA81065 CAA81066 EAW85523 EAW85524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca