Version 5.4
Homo sapiens Gene: ECI1
Summary
InnateDB Gene IDBG-10272.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECI1
Gene Name enoyl-CoA delta isomerase 1
Synonyms DCI
Species Homo sapiens
Ensembl Gene ENSG00000167969
Encoded Proteins
IDBP-10274
enoyl-CoA delta isomerase 1
IDBP-747704
IDBP-750891
IDBP-752136
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2239395-2252300
Strand Reverse strand
Band p13.3
Transcripts
ENST00000301729 ENSP00000301729
ENST00000563447
ENST00000561688
ENST00000570258 ENSP00000457900
ENST00000563029
ENST00000562238 ENSP00000456319
ENST00000566379 ENSP00000456565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004165 dodecenoyl-CoA delta-isomerase activity
GO:0016860 intramolecular oxidoreductase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024132
View Gene Order
ENSBTAG00000009965
Not yet available
Pathways
NETPATH
REACTOME
REACT_160
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_111217
Metabolism pathway
KEGG
hsa00071
Fatty acid degradation pathway
INOH
PID NCI
Cross-References
SwissProt P42126
TrEMBL
UniProt Splice Variant
Entrez Gene 1632
UniGene
RefSeq NM_001178029 NM_001919
HUGO HGNC:2703
OMIM 600305
CCDS CCDS58410 CCDS10464
HPRD 02628
IMGT
EMBL AK291127 BC000762 BC002746 BC019316 BC020228 CH471112 L24774 Z25820 Z25821 Z25822 Z25823 Z25824
GenPept AAA35485 AAH00762 AAH02746 AAH19316 AAH20228 BAF83816 CAA81065 CAA81066 EAW85524
RNA Seq Atlas 1632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca