InnateDB Protein
|
IDBP-102776.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
INTS3
|
Protein Name
|
integrator complex subunit 3
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000318641
|
InnateDB Gene
|
IDBG-102774 (INTS3)
|
Protein Structure
|
|
Function |
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
|
Protein-Protein |
54
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR019333
Integrator complex subunit 3
|
PFAM |
PF10189
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q68E01
|
PhosphoSite |
PhosphoSite-Q68E01
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
65123
|
UniGene |
Hs.516522
|
RefSeq |
NP_075391
|
HUGO |
HGNC:26153
|
OMIM |
611347
|
CCDS |
CCDS1052
|
HPRD |
08644
|
IMGT |
|
EMBL |
AK025572
AK074979
AK290025
AK298746
AK304874
AL513523
AL832133
BC025254
BC054513
BC073985
BC098431
BC105092
BC105094
BC116458
BK005722
BX640786
BX640950
CH471121
CR627233
CR749212
CR749376
|
GenPept |
AAH25254
AAH54513
AAH73985
AAH98431
AAI05093
AAI05095
AAI16459
BAB15174
BAC11329
BAF82714
BAG60890
BAG65611
CAE45876
CAE45974
CAH10366
CAH10398
CAH18069
CAH18229
CAH71415
CAH71416
CAH71417
CAH71418
DAA05722
EAW53279
EAW53283
|
|
|