Version 5.4
Homo sapiens Gene: INTS3
Summary
InnateDB Gene IDBG-102774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS3
Gene Name integrator complex subunit 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143624
Encoded Proteins
IDBP-102776
integrator complex subunit 3
IDBP-388712
integrator complex subunit 3
IDBP-480463
integrator complex subunit 3
IDBP-810768
integrator complex subunit 3
IDBP-476918
integrator complex subunit 3
IDBP-810772
integrator complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153728067-153774808
Strand Forward strand
Band q21.3
Transcripts
ENST00000318967 ENSP00000318641
ENST00000368670
ENST00000368669
ENST00000435409 ENSP00000404290
ENST00000481797
ENST00000512605 ENSP00000425437
ENST00000476843 ENSP00000485263
ENST00000480659
ENST00000503133 ENSP00000422616
ENST00000491790
ENST00000624515 ENSP00000485502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0010212 response to ionizing radiation
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0032039 integrator complex
GO:0070876 SOSS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027933
View Gene Order
ENSBTAG00000006235
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516522
RefSeq NM_023015 XM_005245461 XM_005276737 XM_006711490 XM_006726204
HUGO
OMIM
CCDS CCDS1052
HPRD 08644
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca