Version 5.4
Homo sapiens Protein: SLC39A1
Summary
InnateDB Protein IDBP-102818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A1
Protein Name solute carrier family 39 (zinc transporter), member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348535
InnateDB Gene IDBG-102816 (SLC39A1)
Protein Structure
UniProt Annotation
Function Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. {ECO:0000269PubMed:12888280}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11696349}; Multi-pass membrane protein {ECO:0000269PubMed:11696349}. Endoplasmic reticulum membrane {ECO:0000269PubMed:11696349}; Multi-pass membrane protein {ECO:0000269PubMed:11696349}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. {ECO:0000269PubMed:10610721}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0022890 inorganic cation transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY26
PhosphoSite PhosphoSite-
TrEMBL Q5T4K4
UniProt Splice Variant
Entrez Gene 27173
UniGene Hs.7854
RefSeq NP_001258887
HUGO HGNC:12876
OMIM 604740
CCDS CCDS1055
HPRD 11984
IMGT
EMBL AF132942 AF151829 AJ243649 AJ243650 AJ271671 AK074943 AK075257 AK297983 AL358472 BC002563 BC003152 BC007886 BC014303 CH471121
GenPept AAD27717 AAD34066 AAH02563 AAH03152 AAH07886 AAH14303 BAC11502 BAG52035 BAG60292 CAB59979 CAB59980 CAB82784 CAI14019 EAW53259 EAW53261 EAW53264 EAW53265 EAW53267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca