Version 5.4
Homo sapiens Gene: SLC39A1
Summary
InnateDB Gene IDBG-102816.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A1
Gene Name solute carrier family 39 (zinc transporter), member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143570
Encoded Proteins
IDBP-102818
solute carrier family 39 (zinc transporter), member 1
IDBP-102820
solute carrier family 39 (zinc transporter), member 1
IDBP-102822
solute carrier family 39 (zinc transporter), member 1
IDBP-102824
solute carrier family 39 (zinc transporter), member 1
IDBP-388736
solute carrier family 39 (zinc transporter), member 1
IDBP-388737
solute carrier family 39 (zinc transporter), member 1
IDBP-388738
solute carrier family 39 (zinc transporter), member 1
IDBP-583286
solute carrier family 39 (zinc transporter), member 1
IDBP-810664
solute carrier family 39 (zinc transporter), member 1
IDBP-810667
solute carrier family 39 (zinc transporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153959099-153968184
Strand Reverse strand
Band q21.3
Transcripts
ENST00000356205 ENSP00000348535
ENST00000368623 ENSP00000357612
ENST00000368621 ENSP00000357610
ENST00000310483 ENSP00000309710
ENST00000429040 ENSP00000392950
ENST00000413622 ENSP00000392229
ENST00000417348 ENSP00000407717
ENST00000461071
ENST00000537590 ENSP00000443632
ENST00000621013 ENSP00000484182
ENST00000617697 ENSP00000479421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005385 zinc ion transmembrane transporter activity
GO:0022890 inorganic cation transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052310
View Gene Order
ENSBTAG00000011284
Not yet available
Pathways
NETPATH
REACTOME
REACT_20603
Zinc influx into cells by the SLC39 gene family pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_20530
Zinc transporters pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743291 Hs.7854
RefSeq NM_001271957 NM_001271958 NM_001271959 NM_001271960 NM_001271961 NM_014437 XM_006711276
HUGO
OMIM
CCDS CCDS1055 CCDS72920
HPRD 11984
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca