InnateDB Protein
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IDBP-102820.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC39A1
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Protein Name
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solute carrier family 39 (zinc transporter), member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357612
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InnateDB Gene
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IDBG-102816 (SLC39A1)
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Protein Structure
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Function |
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. {ECO:0000269PubMed:12888280}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11696349}; Multi-pass membrane protein {ECO:0000269PubMed:11696349}. Endoplasmic reticulum membrane {ECO:0000269PubMed:11696349}; Multi-pass membrane protein {ECO:0000269PubMed:11696349}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. {ECO:0000269PubMed:10610721}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005102
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receptor binding
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GO:0005385
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zinc ion transmembrane transporter activity
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GO:0022890
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inorganic cation transmembrane transporter activity
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GO:0046873
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metal ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003689
Zinc/iron permease
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PFAM |
PF02535
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NY26
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5T4K4
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UniProt Splice Variant |
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Entrez Gene |
27173
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UniGene |
Hs.7854
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RefSeq |
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HUGO |
HGNC:12876
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OMIM |
604740
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CCDS |
CCDS1055
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HPRD |
11984
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IMGT |
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EMBL |
AF132942
AF151829
AJ243649
AJ243650
AJ271671
AK074943
AK075257
AK297983
AL358472
BC002563
BC003152
BC007886
BC014303
CH471121
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GenPept |
AAD27717
AAD34066
AAH02563
AAH03152
AAH07886
AAH14303
BAC11502
BAG52035
BAG60292
CAB59979
CAB59980
CAB82784
CAI14019
EAW53259
EAW53261
EAW53264
EAW53265
EAW53267
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