InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB7B

Summary

InnateDB Protein

IDBP-103053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB7B

Protein Name

zinc finger and BTB domain containing 7B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292176

InnateDB Gene

IDBG-103049 (ZBTB7B)

Protein Structure

UniProt Annotation

Function

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007398	ectoderm development
GO:0030154	cell differentiation